M e d i c i n e A v e 2 1 1. 194 INTRODUCING A MAJOR STEP IN THERAPY FOR CENTRAL PRECOCIOUS PUBERTY 1. AGENCY: Flashpoint Medica CREATIVE TEAM: Steve Frederick, Kerry Baker, Barbara Fluber, Rena Menkes CLIENT: Indevus Pharmaceuticals 2. AGENCY: Euro RSCG Life x2 CREATIVE TEAM: Terry Gallo, Stephen Dolleck, Jill Karshmer, Joe Catena, Wendy Taubman CLIENT: Bristol-Myers Squibb The first and only 12-month implant for central precocious puberty LH suppression in 100% of measured patients’ • Suppression seen at 1 month and maintained for a full year with no escapes, even in patients unsuppressed on GnRH agonist depot’ Study dttigo: fnjs* Jl study Ct 36 pettrts 6p«) 45 ta >1.6yeyswtd GrfiH-Oipendeot precocious (yitKrty. 16 caWK KttO/ on Gnfill agcnlsl 05t«x tc» » few 6 ntomris <2 potienti •.vereuisujipr«30d on treaMwo. al DK*«nei. and 20 trrotrrtsrt <\sr*« patients. PrriMSt-3 pstoiocs rox-tad KnpJmis at » txtor* f i?irra ct the* <vx! showed GitfM 9907!51depot injotW, vatu no A-yjcct fffeacy ovaMaton was IH j^ye^on at 1mono. 3 momhs. sod t? months atiw imptont (Oefmecl as Kimialod IH twete << rnliVTiq. Safe and effective once-yearly therapy • Sterile, nonbiodegradable—made of the same material as a soft contact lens • The recommended dose is one 50-mg implant for 12 months—titration not required • In phase 1 clinical trial, 32/33 (97%) of eligible patients opted to receive another imptant after 12 months' 3 5 «n knj a e 3 »vn iVwwxv Supprelin LA subcutaneous implant is Indicated for the treatment of children with centra) precocious puberty (CPP). Imptant insertion and removal is a surgical procedure and should utilize aseptic technique. On occasion, locating and/or removal of implant products have been difficult and imaging techniques were used, including ultrasound. CT. or MRI (note: the histrelin imptant is not radiopaque). Rare events of spontaneous extrusion of the implant have been observed in clinical trials. During Supprelin LA treatment, patients should be evaluated tor evidence of clinical and biochemical suppression of CPP manifestations. ONCE-VEARLV # SUPPRELIN LA (hi tsreSna ce at et )s ub ctuan euosimplant A full year of nonstop childhood
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