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M e d i c i n e A v e 2 mom could be protected sooner This flu season, be more aggressive about treatment and prevention The onfy oral antiviral medication tor adults and children aged 1year effective against influenza types A and B indications and Safety Information TAMIFLU ;< :nd-:ateo for the treatment ot uncomplicated influenza caused by viruses types A and 8 in patents t year and older who have been symptomatic f-y no more than 2 days TAMIFLU is also indicated for the proohywvs of trdtoenza at patients 1year and older in treatment stuftes in aduH patients, the most frequently reported adverse events (incidence >!*«> were nausea and vomiting. Other events reported nunwKSffy mote frequently in patients taking TAMIFLU compared with placebo were fcronchifc. "tscmnia and vertigo. In treatment studies m patents f to 12 years eld. the most frequently repoited adverse event \incidence >lc.»i was vomiiwg Other events reported more frequently in patents tavoa TAMifLU compared with placebo included abdciniu.il pain, epstawl ear tEsotder andconjunctivitis In proptT/k£dsstudies madult patients, adverse events were similar 1oIhose seen in the treatment studies Events reported mote frequently in patients taking TAMIFLU compared with placebo {inckfeitce 1*1%) were nausea • household prophylaxis trial that included patients 1 to 12 years cM. adverse events were consistent with arose observed in pediatric treatment studies, with31 everts oe-og the most frequently observed. TreatmentePeac.•-p. subjects withchronic cardiac and/or respiratory disease has not beenestablished Ko ddference intheincidenceol complications was observed between the treatment and placebo groups in th« population Safety and efficacy of repealed treatment or prophylaxis courses have not been studied in postrfiarVeiug experience, tare cases ot anaphylaxis and serious skm reactions, mctoang tone ep*dermal necrof*sis Stevens-Joltnson syndrome and erytfwma m>vforme, have been reported with TAMIFLU. Vacoaitico is considered thefirst line of defenseagainst influenza. (Vine see 8rid Susr-wry at PrcvcnC>og Information. 1. AGENCY: Sudler & Hennessey CREATIVE TEAM: Jack Hyndman, Laura Tozzo, Steven Hebert, Daryn Henry, Guy Desimini CLIENT: Roche 2. AGENCY: Torre Lazur McCann CREATIVE TEAM: Juliet Alvarez, Jennifer Mulvaney CLIENT: International Osteoporosis Foundation 192

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