T h ii W o r k : P rofessional A dvertising R A V E R Y O P T I O N A L New peel-and-stick Synera ™ The topical analgesic patch12 • Quick—effective in as little as 20 minutes' Self-warming—to facilitate drug delivery’ • Pain relief—demonstrated in adults and children 3 years and older' S Y N E R A " • Allergic or anaphylactoid reactions (urticaria, angioedema, bronchospasm, and shock) to the active or inactive components of Syneracan occur and should be managed by conventional means • Synera “ should also be used with caution in patients receiving class I antiarrhythmics and/or other local anesthetics, because the systemic toxic effects may be additive and potentially synergistic with lidocaine and tetracaine • Avoid contact of Synera"' with the eyes due to potential irritation or abrasion. If contact occurs, immediately wash out the eye with water or saline, and protect it until sensation returns • Safety and effectiveness of Synera" have been established in patients 3 years and older • The heating component contains iron powder, and the patch must be removed before magnetic resonance imaging • Do not cut or remove the top cover of the patch as this could result in thermal injury • In clinical studies, the most common local reactions were erythema (71%), blanching (12%), and edema (12%); these reactions were generally mild, resolving spontaneously soon after treatment • Lidocaine has been shown to inhibit viral and bacterial growth. The effect of Synera" on intradermal injections of live vaccines has not been determined • Synera" is not for home use by patient Please see brief summary of Prescribing Information on next page before using Synera". 175
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