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T h e W o r k : P rofessional A dvertising Now for type 2 and type 1 diabetes F O N L Y insulin worked as long 3. la n tu s Works 24 Hours almost twice as long as NPH once-a-day convenient bedtime dosing Lamtus proven safety profile The adverse events commonly associated with Lantus include the following: hypoglycemia, lipodystrophy, skin reactions (such as injection-site reaction, pruritus, rash) and allergic reactions. Hypoglycemia is the most common adverse effect of insulins, including Lantus. In clinical studies in adult patients there was a higher incidence of treatment- emergent injection-site pain {2.7% Lantus versus 0.7% NPH). The reports of pain at the injection site were usually mild and did not result in discontinuation of therapy. LAN TUS insulinglargine[rDNAorigin] injection WORKS AROUND THE CLOCK WITH JUST ONE SHOT J t^ ^ / fo r dia betcA 24 -hou r Lantus The first and only insulin analog that provides 24-hour glucose-lowering activity with just one shot' For adult patients with type 2 diabetes and adult and pediatric patients (56 years of age) with type 1 diabetes. LANTUS MUST NOT BE DILUTED OR MIXED WITH ANY OTHER INSULIN OR SOLUTION. If mixed or diluted, the solution may become cloudy, and the onset of action/time to peak effect may be altered in an unpredictable manner. 173

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