M e d i c i n e A ve 2 For adult patients with chronic idiopathic constipation • Up to 71% of patients achieved normal bowel function (z3 S8Ms' per week)” • Proven long-term safety profile demonstrated by 6-month and 12-month safety studies’ • The ONLY agent approved for patients 65 years and older Relief is defined as e3 S8Ms pet week. Important Product Information • AMITIZA is mdcafed lot the treatment ol chronic idiopathic constipation m the adult population. • AMITIZA should net be used in patients wrdi a known hypersensitivity to any components of the formutalion and in patients with a history of mechanical gastrointestinal obstruction. Patients with symptoms suggestive ot mechanical gastrointestinal obstiudion should be evaluated prior lo initiating AMITIZA treatment • The safety ot AMITIZA in pregnancy has not been evaluated in humans in guinea pigs, Myptostone has been shown to have the potential lo cause letal loss. AMITIZA should be used during pregnancy only II the benefit justifies the potential risk to the fetus Women who could become pregnant shoutd have a negative pregnancy test prior to beginning therapy with AMITIZA and should be capable ol complying with etfecfive contraceptive measures • AMITIZA should not be administered to patients that have severe diarrhea Patents should be aware ol the possible occurrence ol diarrhea during treatment If the diarrhea becomes severe, patients should consult their health professional. • In dmical trials, the most common adverse event was nausea 131%). Other adverse events (*5% ol patients) included diarrhea (13%), headache (13%), abdominal distention (7%), abdominal pain (7%). flatulence (6%), sinusitis (5%) and vomiting (5%). Ptoaw m 8riot Swnmafy ol Proicrlfctafl InlonnattM on adjicool pi j«. Mtmur 1. Cuu on N* Sounijio PiurmaauDcalt, Ii ''IjUCAMro a m i t i z a lubiprostone A new way to relief Visit AMITIZA Booth #132 to find out more. 1. AGENCY: Saatchi & Saatchi CREATIVE TEAM: Ed Nathan, Martha Crane, Dobbi Massey, Kyle Grazia, Amy Schachter CLIENT: Takeda 2. AGENCY: Torre Lazur McCann CREATIVE TEAM: Jennifer Mulvaney and Team CLIENT: Reckitt Benckiser 168
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