T h e 70 ’s Blood levels with THEO-DUR' anhydrous IhCOphyllifX vs. Blood levels with other forms of oral theophylline: The lines are drawn. THEO-DUR-The first and only form of oral theophylline to demonstrate linear blood levels for a full 12 hours. Unw IHEO DuR Wood levels irom oral theophyllines always snowed wide peak-trough Hue tuations Tn.s meant me drug was difficult to maintain m me therapeutic range and difficult tt Sustain m that range for more than a few hours For most patients, the therapeutic range of thoophyltin fans somewhere between 10 and 20 meg • ml When scrum concentrations fan much beiow •0 the/ are often ITS?«££*“ ’ ineffective • W " " ' When they go much above 20 they are usually toxic Now. with ThEO-OUR. you can provido your pat-eni with maximum theophylline protection ana avoid theophylline failure Ant* smce thEO-DuR maintains therapeutic biood levels for a fu'» 12 nours. patients can en;oy a »uUday o» norma; activities and a n.ghj of umnterrupieo s'.eep Zero-order THEO-DUR -a unique form of oral theophylline. FHEO-OUR produces i>ne«tr serum concen trations because THEO-DUR has zero order abscrpt'or1 The crug is absorbed into the Wood at a constant Quantity per hour Otner ora» forms of theophylline have first- order absorption, m which the largest amount >s absorbed m tne first hour and propon-onatety smaller amounts thereafter Wien absorption varies as it dees -with first- order orugs. protection can also vary That's why first-order theophyllines can be toxic withm tne first few hours and subtherapeutic later on THEO-DUR-the practical benefits. Your patieni benefits from the maximum control provided by ThEO-DUR m several important ways exercise tolerance is increased, emergency hospital visits are !ess »<ke«yand concomitant therapy is usually unnecessary Dosage titration is easy to achieve* THEO-OUR is the only sustained-action tablet m 200 mg as wen as 100 and 300 mg strengths and alt tablets are scored for greater dosage flexibility THEO-DUR also enhances patient compliance- with an every 12 hour dosage schedule mai s easier to remember fOOOV ©• r^yvfomtf j-n/ .IC.'i'CC' J'c Oo%4 <77 THEO-DUR anhydroustheophylline Sustained Action Tablets Today’s most widely-prescribed bronchodilator. 2 3 We straightened out the problem of theophylline blood levels. The problem with theophylline blood level® is that they ate difficult to maintain <nthe therapeutic range and difficult to sustain for more than a few hours. For most patients. |he therapeutic range of theophylline is somewhere between 10 and 20 mcg/mJ. If serum conceniralions (all much below 10. iheophylline is ofien ineffective. If they qo much above 20. they are usually toxic. THEO-DUR is the only form ol oral Iheophylline to oiler linear serum concentralions. II minimizes the peak-trough fluctuations common to many other oral theophyHines. Once titrated, linear serum concentrations assure that THEO-OURwill remain therapeutic. And. 9tnce THEO-DUR maintains therapeutic blood levels for 12 hours, paiienis can en»oy a fui>day of normal activities and a night of uninterrupted sleep. Zero-order THEO-DUR-a unique form of oral theophylline. THEO-DUR produces linear serum concentrations because THEO-OUR has zero-order absorption The drug is absorbed into the blood 81 a consienl quanliiy per hour. Other oral forms of theophylUie have first-order absorpiion. in which (he largest amount Is absorbed in the first hour and proportionately smaller amounts thereafter. When absorpiion varies, as it does with first- order drugs, protection can also vary Thai* why lirst-order theophyllines can be toxic within Ihe first few hours and subtherapeutic later on. THEO-OUR-the practical benefits. Your patient beneliis from the maximum control provided by THEO-DUR in several important ways: exercise tolerance is increased, emergency hospital visits are less likely and concomitant therapy is usually unnecessary Dosage liiration is easy to achieve? THEO-OUR is Ihe only susiained-acilon tablet in 200 mg as well as 100 and 300 mg strengths, and all tablets are scored for greater dosage flexibility. THEO-OUR also enhances patient compfiance- with an every 12 hour dosage schedule that's easier to remember. • Aitti ifcue days. or a steady dose, teojm coneMMtom tnouid Oa morworedand appropnare ctcsape vwvs THEO-DUR anhydrous theophylline Susiained Action Tabrets Today's most widely-prescribed bronchodilator. 63
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